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Graphical contents list • MISCELLANEOUS PDF (324 K) | |||
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The synthesis and structure–activity relationships of 3-amino-4-benzylquinolin-2-ones: discovery of novel KCNQ2 channel openers • SHORT COMMUNICATION Piyasena Hewawasam , Nathan Chen , Min Ding , Joanne T. Natale , Christopher G. Boissard , Sarita Yeola , Valentin K. Gribkoff , John Starrett and Steven I. Dworetzky SummaryPlus | Full Text + Links | PDF (160 K) | |||
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Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists • SHORT COMMUNICATION Shelley Allen , Bradley Newhouse , Aaron S. Anderson , Benjamin Fauber , Andrew Allen , David Chantry , Christine Eberhardt , Joshua Odingo and Laurence E. Burgess SummaryPlus | Full Text + Links | PDF (216 K) | |||
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Evidences for the formation of bisbenzamidine–heme complexes in cell-free systems • SHORT COMMUNICATION Annie Mayence , Jean Jacques Vanden Eynde and Tien L. Huang SummaryPlus | Full Text + Links | PDF (153 K) | |||
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Femtosecond time-resolved guanine oxidation in acridine modified alanyl peptide nucleic acids • SHORT COMMUNICATION D. Weicherding , W. B. Davis , S. Hess , T. von Feilitzsch , M. E. Michel-Beyerle and U. Diederichsen SummaryPlus | Full Text + Links | PDF (208 K) | |||
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Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy- Jerel Banks and David E. Cane SummaryPlus | Full Text + Links | PDF (201 K) | |||
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Synthesis of N -arylhistidine derivatives via direct N-arylation • SHORT COMMUNICATIONWeimin Yue , Stefanie I. Lewis , Yakov M. Koen and Robert P. Hanzlik SummaryPlus | Full Text + Links | PDF (151 K) | |||
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Synthesis of a novel intercalator based on 2,2′-binaphthalene bearing dimethylammonium groups • SHORT COMMUNICATION Shin-ichi Kondo , Tomoko Kinjo and Yumihiko Yano SummaryPlus | Full Text + Links | PDF (151 K) | |||
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Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists • SHORT COMMUNICATION Jeffrey G. Varnes , Daniel S. Gardner , Joseph B. Santella, III , John V. Duncia , Melissa Estrella , Paul S. Watson , Cheryl M. Clark , Soo S. Ko , Patricia Welch et al. SummaryPlus | Full Text + Links | PDF (197 K) | |||
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Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists • SHORT COMMUNICATION Donna M. Huryn , Susan Ashwell , Reinhardt Baudy , Darren B. Dressen , William Gallaway , Francine S. Grant , Andrei Konradi , Robert W. Ley , Susan Petusky , Michael A. Pleiss et al. SummaryPlus | Full Text + Links | PDF (152 K) | |||
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Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization • SHORT COMMUNICATION Todd R. Elworthy , Denis J. Kertesz , Woongki Kim , Michael G. Roepel , Lina Quattrocchio-Setti , David B. Smith , Jahari Laurant Tracy , Audrey Chow , Fujun Li , Emma R. Brill et al. SummaryPlus | Full Text + Links | PDF (203 K) | |||
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Synthesis and evaluation of analogues of S-adenosyl- Christine Guérard , Maud Bréard , Fabienne Courtois , Thierry Drujon and Olivier Ploux SummaryPlus | Full Text + Links | PDF (180 K) | |||
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New synthesis of (S)-dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethenedioxy-biphenyl-2,2′-dicarboxylate by configuration transform • SHORT COMMUNICATION Sen-Xiang Cheng , Jun-Biao Chang , Ling-Bo Qu and Rong-Feng Chen SummaryPlus | Full Text + Links | PDF (142 K) | |||
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Inhibitory activities against topoisomerase I & II by polyhydroxybenzoyl amide derivatives and their structure–activity relationship • SHORT COMMUNICATION Mohamed Abdel-Aziz , Kazuya Matsuda , Masami Otsuka , Masaru Uyeda , Tadashi Okawara and Keitarou Suzuki SummaryPlus | Full Text + Links | PDF (174 K) | |||
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Design and synthesis of macrocyclic inhibitors of phosphatase Cdc25B • SHORT COMMUNICATION Stefan Bäurle , Thorsten Blume , Judith Günther , Daniela Henschel , Roman C. Hillig , Manfred Husemann , Anne Mengel , Christian Parchmann , Elke Schmid and Werner Skuballa SummaryPlus | Full Text + Links | PDF (259 K) | |||
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Tricyclic pyridones as functionally selective human GABAA 2/3 receptor-ion channel ligands • SHORT COMMUNICATIONJames Crawforth , John R. Atack , Susan M. Cook , Karl R. Gibson , Alan Nadin , Andrew P. Owens , Andrew Pike , Michael Rowley , Alison J. Smith , Bindi Sohal et al. SummaryPlus | Full Text + Links | PDF (195 K) | |||
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Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors • SHORT COMMUNICATION Sunil Kumar Singh , Saibaba Vobbalareddy , Samala Shivaramakrishna , A. Krishnamraju , Shaikh Abdul Rajjak , Seshagiri Rao Casturi , Vangoori Akhila and Yeleswarapu Koteswar Rao SummaryPlus | Full Text + Links | PDF (266 K) | |||
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 -Delocalized  -carbolinium cations as potential antimalarials • SHORT COMMUNICATIONKiyosei Takasu , Tsubasa Shimogama , Chalerm Saiin , Hye-Sook Kim , Yusuke Wataya and Masataka Ihara SummaryPlus | Full Text + Links | PDF (176 K) | |||
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N-4-Methansulfonamidobenzyl-N′-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands • SHORT COMMUNICATION Hyeung-geun Park , Ji-yeon Choi , Sea-hoon Choi , Mi-kyung Park , Jihye Lee , Young-Ger Suh , Hawon Cho , Uhtaek Oh , Hee-Doo Kim , Yung Hyup Joo et al. SummaryPlus | Full Text + Links | PDF (180 K) | |||
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Complestatin synthetic studies: the effect of the amino acid configuration on peptide backbone conformation in the common western BCD macrocycle • SHORT COMMUNICATION Amos B. Smith, III , Jason J. Chruma , Qiang Han and Joseph Barbosa SummaryPlus | Full Text + Links | PDF (358 K) | |||
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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum • SHORT COMMUNICATION Marie Gompel , Maryse Leost , Elisa Bal De Kier Joffe , Lydia Puricelli , Laura Hernandez Franco , Jorge Palermo and Laurent Meijer SummaryPlus | Full Text + Links | PDF (198 K) | |||
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The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands • SHORT COMMUNICATION Manish Tandon , Mary-Margaret O'Donnell , Alex Porte , David Vensel , Donglai Yang , Rocio Palma , Alan Beresford and Mark A. Ashwell SummaryPlus | Full Text + Links | PDF (161 K) | |||
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Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis • SHORT COMMUNICATION Tao Guo , Anton E. P. Adang , Roland E. Dolle , Guizhen Dong , Dan Fitzpatrick , Peng Geng , Koc-Kan Ho , Steven G. Kultgen , Ruiyan Liu , Edward McDonald et al. SummaryPlus | Full Text + Links | PDF (209 K) | |||
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Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis • SHORT COMMUNICATION Tao Guo , Anton E. P. Adang , Guizhen Dong , Dan Fitzpatrick , Peng Geng , Koc-Kan Ho , Charles H. Jibilian , Steven G. Kultgen , Ruiyan Liu , Edward McDonald et al. SummaryPlus | Full Text + Links | PDF (206 K) | |||
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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators • SHORT COMMUNICATION Steven W. Elmore , John K. Pratt , Michael J. Coghlan , Yue Mao , Brian E. Green , David D. Anderson , Michael A. Stashko , Chun W. Lin , Douglas Falls , Masaki Nakane et al. SummaryPlus | Full Text + Links | PDF (286 K) | |||
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Betuligenol derivative with growth inhibition and antifeedant activity • SHORT COMMUNICATION Sunil K. Chattopadhyay , Sachin Srivastava , Koneni V. Sashidhara , Arun K. Tripathi , Asish K. Bhattacharya and Arvind S. Negi SummaryPlus | Full Text + Links | PDF (119 K) | |||
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Synthesis and anti-inflammatory activity of some [4,6-(4-substituted aryl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetic acid derivatives • SHORT COMMUNICATION Sushilkumar S. Bahekar and Devanand B. Shinde SummaryPlus | Full Text + Links | PDF (149 K) | |||
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The inhibition of metallo--lactamase by thioxo-cephalosporin derivatives • SHORT COMMUNICATION Wing Y. Tsang , Anupma Dhanda , Christopher J. Schofield , Jean-Marie Frère , Moreno Galleni and Michael I. Page SummaryPlus | Full Text + Links | PDF (139 K) | |||
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Carbazates as potent inhibitors of hormone-sensitive lipase • SHORT COMMUNICATION Johannes C. de Jong , Lotte G. Sørensen , Hans Tornqvist and Poul Jacobsen SummaryPlus | Full Text + Links | PDF (168 K) | |||
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6-Aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays • SHORT COMMUNICATION Roberta Costi , Roberto Di Santo , Marino Artico , Alessandra Roux , Rino Ragno , Silvio Massa , Enzo Tramontano , Massimiliano La Colla , Roberta Loddo , M. Elena Marongiu et al. SummaryPlus | Full Text + Links | PDF (248 K) | |||
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Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists • SHORT COMMUNICATION Chong Hyun Ryu , Mi Jung Jang , Jeong Wha Jung , Ju-Hyun Park , Hye Young Choi , Young-ger Suh , Uhtaek Oh , Hyeung-geun Park , Jeewoo Lee , Hyun-Joo Koh et al. SummaryPlus | Full Text + Links | PDF (191 K) | |||
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A prodrug approach to COX-2 inhibitors with methylsulfone • SHORT COMMUNICATION Joo Hyun Moh , Young Hoon Choi , Kyoung Min Lim , Ki-Wha Lee , Song Seok Shin , Jin Kyu Choi , Hyun Joo Koh and Shin Chung SummaryPlus | Full Text + Links | PDF (151 K) | |||
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Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists • SHORT COMMUNICATION Nagaaki Sato , Takunobu Shibata , Makoto Jitsuoka , Toshiyuki Ohno , Toshiyuki Takahashi , Tomoko Hirohashi , Tetsuya Kanno , Hisashi Iwaasa , Akio Kanatani and Takehiro Fukami SummaryPlus | Full Text + Links | PDF (178 K) | |||
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Protein-dynamics of the putative HCV receptor CD81 large extracellular loop • SHORT COMMUNICATION Alexander Neugebauer , Christian D. P. Klein and Rolf W. Hartmann SummaryPlus | Full Text + Links | PDF (392 K) | |||
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N-Acyl substituted 7-amino-4-chloroisocoumarin: A peptide degradation model via an imide mechanism • SHORT COMMUNICATION Cédrik Garino , FrédéricBihel , Florence Souard , Gilles Quéléver and Jean-Louis Kraus SummaryPlus | Full Text + Links | PDF (172 K) | |||
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Synthesis and nicotinic acetylcholine receptor binding affinities of 2- and 3-isoxazolyl-8-azabicyclo[3.2.1]octanes • SHORT COMMUNICATION Jie Cheng , Sari Izenwasser , Chunming Zhang , Suhong Zhang , Dean Wade and Mark L. Trudell SummaryPlus | Full Text + Links | PDF (156 K) | |||
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Different hydroxyl radical scavenging activity of water-soluble -alanine C60 adducts • SHORT COMMUNICATION Tao Sun , Zhishen Jia and Zhude Xu SummaryPlus | Full Text + Links | PDF (116 K) | |||
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Cyclodextrin trimers as receptors for arranging ester and catalyst at optimized location to achieve enhancement of hydrolytic activity • SHORT COMMUNICATION Hiroki Nakajima , Yuzuru Sakabe , Hiroshi Ikeda and Akihiko Ueno SummaryPlus | Full Text + Links | PDF (206 K) | |||
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Synthesis and stability studies of phosphonoformate–amino acid conjugates: a new class of slowly releasing foscarnet prodrugs • SHORT COMMUNICATION Mong S. Marma , Boris A. Kashemirov and Charles E. McKenna SummaryPlus | Full Text + Links | PDF (133 K) | |||
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Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists • SHORT COMMUNICATION Anandan Palani , Sundeep Dugar , John W. Clader , William J. Greenlee , Vilma Ruperto , Ruth A. Duffy and Jean E. Lachowicz SummaryPlus | Full Text + Links | PDF (192 K) | |||
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Syntheses and structure–activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists • SHORT COMMUNICATION Jinlong Jiang , Robert J. DeVita , Mark T. Goulet , Matthew J. Wyvratt , Jane-L. Lo , Ning Ren , Joel B. Yudkovitz , Jisong Cui , Yi T. Yang , Kang Cheng and Susan P. Rohrer SummaryPlus | Full Text + Links | PDF (179 K) | |||
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Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites • SHORT COMMUNICATION Huw M. L. Davies , Darrin W. Hopper , Tore Hansen , Quixu Liu and Steven R. Childers SummaryPlus | Full Text + Links | PDF (233 K) | |||
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Efficient and chemoselective N-acylation of 10-amino-7-ethyl camptothecin with poly(ethylene glycol) • SHORT COMMUNICATION Andrea Guiotto , Mirta Canevari , Piero Orsolini , Olivier Lavanchy , Christine Deuschel , Norimasa Kaneda , Akinobu Kurita , Takeshi Matsuzaki , Takeshi Yaegashi , Seigo Sawada and Francesco M. Veronese SummaryPlus | Full Text + Links | PDF (134 K) | |||
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Synthesis of potent sigma-1 receptor ligands via fragmentation of dextromethorphan • SHORT COMMUNICATION Mark P. Arrington , Claire Brown and C. Eric Schwartz SummaryPlus | Full Text + Links | PDF (142 K) | |||
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Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium • SHORT COMMUNICATION Ronald A. Forsch , Sherry F. Queener and Andre Rosowsky SummaryPlus | Full Text + Links | PDF (172 K) | |||
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Corrigendum to "Structure–activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors" [Bioorg. Med. Chem. Lett. 13 (2003) 4085] • ERRATUM Hidekazu Masaki , Yusuke Mizuno , Akira Tatui , Akira Murakami , Yuuki Koide , Shoji Satoh and Atsuo Takahashi SummaryPlus | Full Text + Links | PDF (94 K) | |||
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Corrigendum to "Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage" [Bioorg. Med. Chem. Lett. 14 (2004) 611] • ERRATUM Christos A. Kontogiorgis and Dimitra J. Hadjipavlou-Litina SummaryPlus | Full Text + Links | PDF (67 K) | |||
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Editorial board • MISCELLANEOUS PDF (57 K) | |||
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Contributors to this issue • MISCELLANEOUS PDF (55 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (109 K) | |||
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